Self-reproducing protein aggregates of a fibrillar nature (amyloids) are associated with a number of animal and human diseases. Some amyloids (prions) possess infectious pr... in detail

Amyloids are proteins which exist in the form of insoluble aggregates and possess a characteristic cross-beta structure. The formation of amyloid aggregates can be seen dur... in detail

Cancer remains the leading cause of death due to a wide range of molecular mechanisms. One of these mechanisms is impaired proteostasis, which leads to the formation of amy... in detail

Alzheimer’s disease (AD) is the most common form of dementia, characterized by neuronal degeneration and death. The appearance of aggregated forms of the Aβ42 peptide is a ... in detail

Задача равномерного масштабирования предельно малых количеств ДНК из отдельных клеток для молекулярно-генетических исследований потребовала разработки специализированных ме... in detail

Amyloids are fibrillar proteins with a cross-β structure. Pathological amyloids are associated with the development of a number of incurable diseases, while functional amyl... in detail

The RNA-guided Cas12a nuclease forms a complex with a CRISPR RNA (crRNA) to cleave the double-stranded DNA target. Among others, Cas12a protein from Lachnospiraceae ba... in detail

Amyloids are fibrous cross-β protein aggregates that are capable of proliferation via nucleated polymerization. Amyloid conformation likely represents an ancient protein fo... in detail